Genome-Scale Algorithm Design: Biological Sequence Analysis by Veli Mäkinen,Djamal Belazzougui,Fabio Cunial,Alexandru I.

By Veli Mäkinen,Djamal Belazzougui,Fabio Cunial,Alexandru I. Tomescu

High-throughput sequencing has revolutionised the sphere of organic series research. Its program has enabled researchers to deal with very important organic questions, usually for the 1st time. This e-book offers an built-in presentation of the basic algorithms and information buildings that strength sleek series research workflows. the themes lined diversity from the principles of organic series research (alignments and hidden Markov models), to classical index buildings (k-mer indexes, suffix arrays and suffix trees), Burrows–Wheeler indexes, graph algorithms and a couple of complicated omics functions. The chapters function a number of examples, set of rules visualisations, routines and difficulties, every one selected to mirror the stairs of large-scale sequencing tasks, together with learn alignment, version calling, haplotyping, fragment meeting, alignment-free genome comparability, transcript prediction and research of metagenomic samples. every one organic challenge is observed through particular formulations, offering graduate scholars and researchers in bioinformatics and desktop technological know-how with a strong toolkit for the rising purposes of high-throughput sequencing.

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