In vivo Models for Drug Discovery, Volume 62 (Methods and by José Miguel Vela,Rafael Maldonado,Michel Hamon

By José Miguel Vela,Rafael Maldonado,Michel Hamon

This one-stop reference is the 1st to offer the total photograph -- protecting all appropriate organisms, from unmarried cells to mammals, in addition to all significant illness components, together with neurological issues, melanoma and infectious diseases.
Addressing the wishes of the pharmaceutical undefined, this designated guide adopts a large standpoint at the use of animals within the early a part of the drug improvement method, together with regulatory principles and barriers, in addition to a variety of examples from real-life drug improvement tasks.
After a common advent to the subject, the professional members from research-driven pharmaceutical businesses speak about the elemental issues of utilizing animal versions, together with moral concerns. the most a part of the booklet systematically surveys crucial sickness components for present drug improvement, from cardiovascular to endocrine problems, and from infectious to neurological ailments. for every region, the supply of animal versions for objective validation, hit discovering and lead profiling is reviewed, subsidized via a variety of examples of either successes and screw ups one of the use of animal types. the complete is rounded off with a dialogue of views and challenges.
Key wisdom for drug researchers in in addition to academia.

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