Lead Generation: Methods and Strategies (Methods and by Jörg Holenz

By Jörg Holenz

during this entire two-volume source at the subject senior lead new release medicinal chemists current a coherent view of the present tools and techniques in commercial and educational lead new release. this can be the 1st booklet to mix either average and cutting edge ways in related breadth and intensity, together with a number of fresh profitable lead new release case experiences released the following for the 1st time.
starting with a normal dialogue of the underlying rules and techniques, person lead iteration techniques are defined intimately, highlighting their strengths and weaknesses, besides all appropriate bordering disciplines like e.g. goal id and validation, predictive equipment, molecular popularity or lead caliber matrices. Novel lead iteration ways for tough goals like DNA-encoded library screening or chemical biology techniques are taken care of the following part through facet with confirmed equipment as excessive throughput and affinity screening, wisdom- or fragment-based lead iteration, and collaborative techniques. in the complete publication, a really powerful concentration is given to focus on the appliance of the awarded tools, in order that the reader should be capable of research from genuine lifestyles examples. the ultimate a part of the ebook offers a number of lead iteration case stories taken from diversified healing fields, together with diabetes, cardiovascular and respiration ailments, neuroscience, an infection and tropical diseases.
the result's a first-rate wisdom source for medicinal chemists and for each scientist serious about lead generation.

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