By Jörg Holenz
starting with a normal dialogue of the underlying rules and techniques, person lead iteration techniques are defined intimately, highlighting their strengths and weaknesses, besides all appropriate bordering disciplines like e.g. goal id and validation, predictive equipment, molecular popularity or lead caliber matrices. Novel lead iteration ways for tough goals like DNA-encoded library screening or chemical biology techniques are taken care of the following part through facet with confirmed equipment as excessive throughput and affinity screening, wisdom- or fragment-based lead iteration, and collaborative techniques. in the complete publication, a really powerful concentration is given to focus on the appliance of the awarded tools, in order that the reader should be capable of research from genuine lifestyles examples. the ultimate a part of the ebook offers a number of lead iteration case stories taken from diversified healing fields, together with diabetes, cardiovascular and respiration ailments, neuroscience, an infection and tropical diseases.
the result's a first-rate wisdom source for medicinal chemists and for each scientist serious about lead generation.
Read Online or Download Lead Generation: Methods and Strategies (Methods and Principles in Medicinal Chemistry) PDF
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